Wednesday, January 18, 2017

Omega 3 & Islet Autoimmunity

Article Title: Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young

Authors: 
  • Jill M. Norris, 
  • Miranda Kroehl, 
  • Tasha E. Fingerlin, 
  • Brittni N. Frederiksen 
  • Jennifer Seifert, 
  • Randall Wong
  • Michael Clare-Salzler, and 
  • Marian Rewers


  • Source: Diabetologia 

    Date: 16 November 2013

    Link: http://link.springer.com/article/10.1007/s00125-013-3106-7

    Summary: A Daisy Project launched involving the study in youngs and they have concluded that DPA levels correlate with IA which triggers diabetes in the young who genetically show capability of having diabetes.



    11 comments:

    1. Learned: If you have a lower-level of omega-3s, you are more likely to get IA which leads to Type 1 Diabetes

      Question: How do omega-3s prevent IA?

      ReplyDelete
    2. DAISY study concluded that Omega-3 supplements decreased Type 1 diabetes in children, but it is inconclusive whether the benefits came from the PUFAs in the supplements or the vitamin D in them.

      Is vitamin D known to have beneficial properties in fighting Type 1 diabetes?

      ReplyDelete
    3. Learned: Children who took DHA supplements had a lower chance of getting Type 1 diabetes, however, this could also be the result of vitamin D.

      Question: Because Type 1 diabetes is genetic, could a parent take DHA supplements and vitamin D supplements to lower the chance their child has of getting Type 1 diabetes?

      ReplyDelete
    4. Type 1 diabetes caused by islet autoimmunity (destroys insulin producing beta cells) and either vitamin D or PUFAs can prevent this issue.
      Could a placebo controlled study prove whether this IA was prevented by PUFAs or vitamin D in order to prevent type 1 diabetes in the future?

      ReplyDelete
    5. Elevated levels of PUFA's in the blood (or possibly vitamin D) reduced the chances of attracting Islet Autoimmune disease and therefore Type 1 diabetes.

      Is Islet Autoimmune disease something you are born with? If not, what causes it and how do omega-3s prevent this?

      ReplyDelete
    6. Kids that did not have IA disease had higher levels of n-3s. Since the children that had IA have less n-3s, is this something that if given at a young age, PUFA supplementation could lessen the symptoms of IA?

      ReplyDelete
    7. What I learned: Omega-3's could potentially lead to a decreased auto-immunity disfunction which could in turn prevent type 1 diabetes. However, these results could be confounded with the lack of Vitamin D.

      Question: Are there any other studies that explore this correlation without the confounding variable of the presence of Vitamin D.

      ReplyDelete
    8. Learned: the higher the Omaga-3, the lower chance of having diabetes.
      Question: How what's the mechanism of getting diabetes? What's the mechanism of omega-3 lowering chance of diabetes?

      ReplyDelete
    9. High levels of DHA supplementation in children lowered the risk of children getting Islet Autoimmunity which leads to Type 1 diabetes.

      What is the relationship between the effects of DHA and Vitamin D in supplementation?

      ReplyDelete
    10. Two questions:
      (1) What are the symptoms of IA prior to getting diabetes?
      (2) What is mechanism of the effect on pancreatic islet?

      ReplyDelete
    11. The pancreas contains beta cells that produce insulin. When these beta cells are affected not enough insulin is created.

      If type 1 and 2 diabetes have no connection why do they both share parts of their names?

      ReplyDelete