Facts: 1. After a heart attack, the heart goes through two major types of reconstruction. One is electrical remodeling (restores permanent correct heart rate) and the other is structural remodeling (builds scar tissue) 2. MAPK's (Mitogen activated protein kinases), which, in the case of heart attack remodeling, guide pro-inmflamatory cytokines toward damaged areas, are inhibited by the double bond of Omega-3. 3. GLAs is a "precursor" to AA fatty acids, and are a good anti-inflammatory. Questions: 1. Scar tissue is referred to as "bad" since it decreases heart flexibility, but is a certain amount required to fix damaged areas from a heart attack? 2. Is a "balance" of Omega-3's, Omega-6's, and saturated fats required to minimize damage in heart remodeling, or is it "the more Omega-3's the better?"
Facts: 1. Dogs injected with omega-3's had significantly less scar tissue build up than dogs who were not injected with omega-3's. 2. MAPK's are pro-inflammatory cytokines, which react to the damage in the heart do to heart attacks. 3. Even though GLA and AA are both omega-6 fatty acids, they have different influences on inflammatory response and stress response. GLA reduces inflammatory sickness, and AA increases inflammatory and stress.
Question: 1. Omega-3's are shown to have helped decrease the accumulation of scar tissue in the heart. Do Omega-6's have any adverse effect? 2. Are MAPK's pro-inflammatory cytokines similar to the effects of the pro-inflammatory omega-6's?
2 Questions: What is the purpose of MAPK's in the body if they hurt you?
Also, why does the body create such a dramatic inflammatory response? Is there a way to prevent the inflammatory response from happening instead of just fighting it with omega-3's?
Connection: This video connects to mine in both of their focus on the inflammatory response. Ellen found that the inflammatory response is hindered by omega-3's and 6's. My video took this further showing how an over consumption of these fatty acids can have negative health effects from the body not being able to fight off diseases.
Ellen, You have a lot of significant findings presented in your slide show. I am eager to see your AP Biology background come into play as you elaborate on some of these ideas.
Could you see if you could find a mechanism for the inhibition of linoleic acid to GLA by AA? Specifically, what is the AA doing (on a molecular level) that prevents the transformation?
Also, I'm getting lost in all these hormones and terms. Could you create a chart or something that shows relationships/differences among the terms: prostaglandin, eicosanoid, corticosterone.
Facts:
ReplyDelete1. After a heart attack, the heart goes through two major types of reconstruction. One is electrical remodeling (restores permanent correct heart rate) and the other is structural remodeling (builds scar tissue)
2. MAPK's (Mitogen activated protein kinases), which, in the case of heart attack remodeling, guide pro-inmflamatory cytokines toward damaged areas, are inhibited by the double bond of Omega-3.
3. GLAs is a "precursor" to AA fatty acids, and are a good anti-inflammatory.
Questions:
1. Scar tissue is referred to as "bad" since it decreases heart flexibility, but is a certain amount required to fix damaged areas from a heart attack?
2. Is a "balance" of Omega-3's, Omega-6's, and saturated fats required to minimize damage in heart remodeling, or is it "the more Omega-3's the better?"
Facts:
ReplyDelete1. Dogs injected with omega-3's had significantly less scar tissue build up than dogs who were not injected with omega-3's.
2. MAPK's are pro-inflammatory cytokines, which react to the damage in the heart do to heart attacks.
3. Even though GLA and AA are both omega-6 fatty acids, they have different influences on inflammatory response and stress response. GLA reduces inflammatory sickness, and AA increases inflammatory and stress.
Question:
1. Omega-3's are shown to have helped decrease the accumulation of scar tissue in the heart. Do Omega-6's have any adverse effect?
2. Are MAPK's pro-inflammatory cytokines similar to the effects of the pro-inflammatory omega-6's?
2 Questions:
ReplyDeleteWhat is the purpose of MAPK's in the body if they hurt you?
Also, why does the body create such a dramatic inflammatory response? Is there a way to prevent the inflammatory response from happening instead of just fighting it with omega-3's?
Connection:
This video connects to mine in both of their focus on the inflammatory response. Ellen found that the inflammatory response is hindered by omega-3's and 6's. My video took this further showing how an over consumption of these fatty acids can have negative health effects from the body not being able to fight off diseases.
Ellen,
ReplyDeleteYou have a lot of significant findings presented in your slide show. I am eager to see your AP Biology background come into play as you elaborate on some of these ideas.
Could you see if you could find a mechanism for the inhibition of linoleic acid to GLA by AA? Specifically, what is the AA doing (on a molecular level) that prevents the transformation?
Also, I'm getting lost in all these hormones and terms. Could you create a chart or something that shows relationships/differences among the terms: prostaglandin, eicosanoid, corticosterone.
You're doing a great job diving into the details!