Benefits of Omega-3 on aged SHR

Link:https://www.researchgate.net/publication/5479998_Aged_male_and_female_spontaneously_hypertensive_rats_benefit_from_n-3_polyunsaturated_fatty_acids_supplementation
Title: Aged male and female spontaneously hypertensive rats benefit from n-3 polyunsaturated fatty acids supplementation
Author: M. MITAŠÍKOVÁ, S. ŠMIDOVÁ1, A. MACSALIOVÁ, V. KNEZL2, K. DLUGOŠOVÁ, Ľ. OKRUHLICOVÁ, P. WEISMANN3, N. TRIBULOVÁ

Summary:
       The experiments are conducted on 14 month-old spontaneously hypertensive rats(SHR) for 2 months. There are two groups: one group of 24 receives omega-3 polyunsaturated fatty acid, and the other group of 24 doesn't. At the end of the experiment, the SHRs' body weight and blood pressure are measured. With these data, the cardioprotective effects of omega-3 are investigated. The result shows several improvements: the decline of blood pressure, suppression of ventricular fibrillation, preservation of cardiomyocytes, enhancement of metabolism enzyme activity, and augmentation of capillary density. Because of increase of alkaline phosphatase (AIP) and suppression of DPP4 activity, the results indicate Omega-3 affects capillary endothelium function. AIP breaks down phosphate esters and has high activities in cell membranes, such as capillary endothelium. And, the data shows that untreated SHRs have lower capillary AIP and higher DPP4 activity. The suppression of DPP4 activity by Omega-3 can be beneficial for aged hypertensive rat heart. The conclusion is both male and female SHRs benefit from omega-3 polyunsaturated fatty acid because of the suppression of arrhythmias, though the mechanisms need further studies.