Katherine L. Wisner, M.D., M.S.; John M. Davis, M.D.;
David Mischoulon, M.D., Ph.D.; Malcolm Peet, M.B., F.R.C.Psych.;
Paul E. Keck, Jr., M.D.; Lauren B. Marangell, M.D.; Alexandra J. Richardson, Ph.D.; James Lake, M.D.; and Andrew L. Stoll, M.D.
Title: Omega-3 Fatty Acids: Evidence Basis for
Treatment and Future Research in Psychiatry
Link: https://www.researchgate.net/publication/6606932_Omega-3_fatty_acids_Evidence_basis_for_treatment_and_future_research_in_psychiatry
Article Date: January 2007
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Article Date: January 2007
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Author: Omega-3 DHA and EPA for Cognition, Behavior, and Mood: Clinical Findings and Structural Functional Synergies with Cell Membrane Phospholipids
Title: Parris M. Kidd, PhD
Link: https://www.researchgate.net/profile/Parris_Kidd2/publication/5775265_Kidd_P_M_Omega-3_DHA_and_EPA_for_cognition_behavior_and_mood_clinical_findings_and_structural-functional_synergies_with_cell_membrane_phospholipids_Altern_Med_Rev_12_207-227/links/56fa1af508ae38d710a307e3.pdf
Article Date: October 2007
Arachidonic acid (AA) is an omega-6 polyunsaturated fatty acid. It competes for membrane space with EPA and DHA. AA creates pro-inflammatory eicosanoids which are believed to exacerbate dysfunction of immune, cardiovascular, retnal, bone, and central nervous systems. The omega-6 fatty acid EPA competes with AA for enzymatic action. This competition reduces the inflammatory response by EPA. EPA is crucial to provide anti-inflammatory effects by balancing the pro-inflammatory responses of AA. AA are not altogether "bad" fatty acids. They are "bad" with the chronically unbalanced American diet. The disproportionate EPA/AA ratio can lead to heightened risk for pro-inflammatory events that foster degenerative diseases.
Article Date: October 2007
Arachidonic acid (AA) is an omega-6 polyunsaturated fatty acid. It competes for membrane space with EPA and DHA. AA creates pro-inflammatory eicosanoids which are believed to exacerbate dysfunction of immune, cardiovascular, retnal, bone, and central nervous systems. The omega-6 fatty acid EPA competes with AA for enzymatic action. This competition reduces the inflammatory response by EPA. EPA is crucial to provide anti-inflammatory effects by balancing the pro-inflammatory responses of AA. AA are not altogether "bad" fatty acids. They are "bad" with the chronically unbalanced American diet. The disproportionate EPA/AA ratio can lead to heightened risk for pro-inflammatory events that foster degenerative diseases.
I think you need to proofread your summary. There were a couple sentences that were oddly written.
ReplyDeleteSuggestions: Find a diagram of how EPA and DHA are arranged in membrane space. Find a diagram of how AA competes (wins) for that space. Find mechanisms for the enzymatic action and how that affects the anti-inflammatory effects of EPA. Does this competition of AA/EPA/DHA occur only in neurons?