Author: Jianguang Su, Kai Quan, Kun Fan, Jiaying Zhang, Jingfang Liu, Wei Hua, Ying Mao
Source: www.ijcem.com
Link: http://www.ijcem.com/files/ijcem0039219.pdf
Source publish date: November 30, 2016
Summary:
Researchers in this research is working to find out the protective effect of high omega-3 diet on delayed blood brain barrier dysfunction in post-traumatic brain injury using mice model. There are several significant results of the lab. First, the high omega-3 diet helps the brain after traumatic brain injury. The brain injury and cerebral edema is less extensive in mice with high omega-3 diet. The cerebral edema attenuated in high omega-3 group as well, indicating the protective effect. Second, high omega-3 diet help reduce the amount of 4-HNE in production. 4-HNE is known as a biomarker of oxidative stress. It also enhances the tight junction proteins shown by the increase of ZO-1 and Occludin. These proteins are crucial in cell communication. Third, 4-HNE inhibitor helps protect the post-TBI brain as well. When 4-HNE inhibitor is injected into the low omega-3, the cerebral edema shows less damage as well. They hypothesize that there’s correlation between Omega-3 and 4-HNB inhibitor. Fourth, high omega-3 diet helps increase recovery speed of cognitive function. Using the water maze test, the researcher find out that high omega-3 group has shorter escape latency, longer time in target quadrant, and higher number of platform crossing. These means high Omega-3 diet could improve the spatial learning and memory function.
Cerebral edema is one of the biggest risk factor in Blood Brain Barrier dysfunction. The researchers speculate mechanism of how Omega-3 and Omega-6 affect the BBB dysfunction is related to the metabolites of them. The product of Omegs-3 peroxidation is 4-HHE known to protect the brain. The product of Omega-6 peroxidation is 4-HNE which has carbonyl group to cause protein carbonylation effecting the function. The result is the changes of permeability of endothelial cells caused by changing in tight junction protein.
Omega-3s decrease the amounts of 4HNE's in the brain, which are a marker of oxidative stress.
ReplyDeleteWhat is the mechanism behind this?
A diet high in omega-3s can help the brain heal and recover in a variety of ways after a traumatic brain injury
ReplyDeleteWhat constitutes cerebral edema? On a biological scale, what are the effects of cerebral edema?
In brains that experienced trauma high levels of omega 3 helped with injury. Less area of the brain was damaged as a result of the omega-3's.
ReplyDeleteAre the Omega-3's preventing the injury in the first place or helping the brain heal quicker?
Increased intake of omega 3 fatty acids could decrease disfunction within the blood-brain barrier.
ReplyDeleteIs there a point where increased permeability of the endothelial cells reaches to great of a degree?
Omega 3's were shown to protect the brain from blood brain barrier dysfunction caused by traumatic contact by utilizing the protein HNE.
ReplyDeleteHow does the production of omega 6's and the ratio of omega'6: omega 3's affect this process?
There is a bi-product of Omeaga-3 peroxidation which is 4-HHHE which is known to protect the brain.
ReplyDeleteHow does 4-HHE protect the brain?
When you suffer a brain injury such as a concussion, omega-3's will help with the recovery, this may be due repair of the blood brain barrier.
ReplyDeleteCould an excess of 4-HHE be harmful to our bodies, as well as 4-HNE?
This was a study finding connections between BBB & a high omega-3 diet that discovered a connection with omega-3s & 4-HNE inhibitor. (4-HNE is a biomarker of oxidative stress.)
ReplyDeleteHow does a tight junction work? Specifically, as the levels of 4-HNE rise, what does this do (on a molecular basis) that causes a decrease in cognitive ability?
There is a connection between omega-3s and the 4HNE inhibitor, and omega-6s help make HNE.
ReplyDeleteThe fact that omega-3's help limit the stress on the cerebral edema is interesting. I think we should go more in depth about how exactly the omega-3s help decrease damage.